Adriana Soria joined the American Army during World War II where she was entered into a program attempting to recreate the Captain America super soldier serum. She and others thought to be likely candidates were posted near the Bikini Atoll islands where nuclear tests were being performed and purposefully exposed to massive amounts of radiation. All the other members of her group died of radiation poisoning, but Adriana survived somehow, although no powers surfaced at first. She was driven mad from the stress of the experience and spent years in an asylum.
Decades later she resurfaced having gained the ability to control anyone who had the “insect gene” and calling herself The Queen. Spider-Man was unable to resist her mind control, and she chose him as her perfect mate. She infected Spider-Man with a mutagen that gradually changed him into a giant spider. Adriana planned to use Spider-Man in his giant spider form to create an army of her spider offspring, but due to the rapid nature of the mutation, the massive creature appeared to die. In a rage she destroyed her own facilities with telekinetic powers and fled. After she left, the giant spider’s abdomen split apart and a freshly reborn Peter Parker emerged, now with enhanced powers and the ability to generate organic webbing.
Later, The Queen showed up again, now teamed up with The Jackal. Now calling herself The Spider-Queen, she was the mastermind behind the Spider-Island plan to transform all of the populous into spiders so that she would be able to control every single person in the city, including the super heroes that might otherwise try to stop her. The Jackal created genetically altered bed bugs that would infect anyone they bit with a mutagen that would first give them powers similar to Spider-Man’s, but then further mutate them into giant spiders. The Jackal tested the mutagen, first by experimenting on Kaine, then on Captain America to see if the plans would work, which they did.
It was only until Spider-Man managed to create a cure at Horizon Labs that the people of New York were saved, and Spider-Queen was defeated.
Among her vast powers, she had enhanced strength, telepathy, telekinesis, psychic blasts, the ability to control insects and those with the “insect gene”, a sonic scream, shape changing into a giant spider monster, and also the ability to draw power off of her mutated victims making her vastly more powerful. She was deemed an Omega-Level threat, and was only defeated because once Spider-Man cured all the people of New York, her powers decreased enough to be killed.